Knowledge-Based Regime

Knowledge is what everyone is ultimately after. So what is it and how is it acquired?  What in the material world would be worth pursuing?  I believe The form of wellness is absolutely a worth it.  But why the dispute?

The science is all figured out, so only one winner can be crowned.  Why sense perception and experience does not equal knowledge...so why are people so inept at knowing once. The proper reasoning and science are presented?  Lets find out!