Weston's biggest solo hits were "Take Me in Your Arms (Rock Me a Little While)" (R&B #4, Pop #50, 1965, later covered by The Isley Brothers, Blood, Sweat & Tears and The Doobie Brothers, and "Helpless" (R&B #13, Pop #56, 1966, previously recorded by The Four Tops on their Second Album LP). Her biggest claim to fame was singing the classic hit "It Takes Two" with Marvin Gaye in 1966 and her later recording of the Black National Anthem, "Lift Every Voice and Sing". It was the success of "It Takes Two"
She and her then-husband William "Mickey" Stevenson both atMGM Records. Weston cut a couple of singles for MGM, "I Got What You Need," and "Nobody," which went largely unnoticed due to lack of airplay and promotion. She made an album for the label, This Is America, which included her popular version of the Black National Anthem, "Lift Every Voice and Sing." This was released as a single and featured in the movie Wattstax. All the money from the single was donated to the United Negro College Fund.