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Despite Dean’s (Jensen Ackles) directive to forget about looking for a cure for the Mark of Cain, Sam (Jared Padalecki) continues to do research. Dean suspects Sam is hiding something but decides to focus on a new murder case where they run into Cole (guest star Travis Aaron Wade). The three team up and learn a Khan worm is infecting men and turning them into murderers. Unfortunately, the worm makes it’s way into Cole. John Badham directed this episode written by Jenny Klein (#1015).