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Patrika Darbo has been featured in numerous stage, film and television credits.
Darbo appeared as Penny Baker on Step by Step (1991–1992). In 1994, she starred as Roseanne Barr in an NBC television movie, Roseanne and Tom: Behind the Scenes. She also starred as Miss Spencer in the 1998 made-for-tv-film Ruby Bridges. From 1998 to 2005, Darbo played Nancy Wesley on the NBC soap opera Days of our Lives, a role that earned her an Emmy nomination for outstanding supporting actress in 2000.
Darbo was a guest star in two Seinfeld episodes; The Revenge in 1991 and The Sniffing Accountant in 1993. Later, in 2010, she also guest starred in Showtime's Dexter as a landlady.
In 2012, Darbo played Grams in Mickey Matson and the Copperhead Conspiracy.
Darbo has recently reprised her role as Nancy Wesley on Days of our Lives.