This episode features returning Guests Amy and Jessica Cowin. Amy Cowin was featured in Season 11 of "Heart to Heart with Anna" in the Heart Warrior Siblings series. She is a heart-healthy sister. Jessica Cowin is Amy's older sister who was born with hypoplastic left heart syndrome and was featured in Episode 3 of Season 1 of "Heart to Heart with Anna." Jessica has had both a heart and kidney transplant. In this program, Jessica and Amy will talk about Jessica's early health issues, her transplants, what they are doing now to help medical science and how their experiences are helping them now to cope with their mother's recent health issues.