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Myeloma is not a single disease. Two types of high-risk myeloma have swapped chromosomes (14;16) and (14;20) have notoriously short survival times with conventional treatments and are found to be resistant to bortezomib, one of the standard myeloma therapies. Dr. Frank Zhan, MD, PhD of the University of Iowa searched a genetic database to identify 100 genes uniquely deregulated for these two types of myeloma. Based on database matching to find compounds that induce or reverse desired gene changes, he found 5 targets to affect the c-MAF and MAFB genes that are disregulated by these translocations. They found that only Alsterpaullon (ALP) significantly inhibits MM cell growth with “spike” expression of either c-MAF or MAFB. ALP is a cyclindependent kinase (CDK) inhibitor and blocks cell-cycle progression. However, the reasons for its antiproliferative effects is unknown. The research will test whether ALP is able to disable c-MAF/MAFB signaling events, thus rendering MM responsive to chemotherapeutics.
Join us for this 6th show of the Myeloma Crowd Research Initiative with Dr. Frank Zhan, MD, PhD and Dr. Guido Tricot, MD, PhD to discuss a potential solution for these patients in a truly personalized medicine fashion.
#173: Marla Looper, Head Coach, Iowa Softball, visits TCRS for the first time to discuss the home opener and B1G opener against Maryland. Games vs Maryland will be tonight at 4pm, Saturday at 2pm and Sunday at 1pm. Sunday's game will air on BTN Plus. Coach Looper concluded her fourth season as the head coach for the University of Iowa softball program in 2014. Looper owns an 100-104-1 overall and 42-48 Big Ten Conference record since the 2011 season. Looper collected her 100th career victory in the 2014 season finale, when Erin Erickson delivered a walkoff, two-run home run to lift the Hawkeyes past Ohio State, 3-2. On the season, Iowa posted 16 wins -- nine in conference action and three over ranked opponents (16-30-1). Megan Blank earned her third-straight first team All-Big Ten honor and was a second team NFCA All-Midwest Region selection after leading the Hawkeyes in batting average, slugging percentage, hits, doubles, triples, RBIs and walks. Kayla Massey earned her second career Big Ten Pitcher of the Week nod on March 31 after recording two complete game wins over Wisconsin. Hawkeyes Twitter, Hawkeyes Facebook.
Wow it's official "Its Real Talk Radio" has been on the air for 2 years strong and we have not let up yet. We can take it a step further and say we're better than ever as far as our content and knowing who we are. That's right, tonight we celebrate our 2 year anniversary of being on air bringing our listeners (you guys) a weekly show faithfully. It's been a long 2 years filled with ups and downs. We've learned a lot and are wiser adults because of this show.
We'll be remenicing on past shows while discussing plans for future shows and where plan on taking the movement. Big shotout to all of our listeners and supporters because we woudn't be where we are right now if it wasn't for you and we promise to not change and continue to give you what you come to us for. Unpredictable, debatable, hilarious, epic discussions with great guest appearances.
It's going down 9PM ET! Make sure you don't miss history. 2 years & counting!!!
RevKess and Kalisara try to bring you a wide variety of authors and artists within Paganism, including those focused on lesser-known traditions. From the Daughters of Shining Harmony website: "Filianism is the Faith of God the Mother and Her Celestial Daughter. It also incorporates the Seven Great Angels, and other feminine Angelic beings."
A Year with Dea is a companion book to Rose Petals: A Filianic Psalter. A Year with Dea provides daily meditations for followers of Dea, in the Filianic tradition. Meditations are presented with the dates of both the Filianic liturgical year and the Julian calendar.
Brythwen Sinclair is the author of A Year with Dea and Rose Petals, and will be joining us to talk about her books, as well as Filianism in general.
One year anniversary celebration! Join Host Charlana Kelly and special guests for a fun hour of congratulations and giveaways. Call 347-945-5050 between 11am and Noon. Thank you gifts to every listener who calls! Also Travis Stewart, Jesus-Way Jamaica, Tim Devolve, Patriotic Remnant, Yolanda East, Shepherd's Lighthouse, among others will join me! Don't miss it!
Join author, speaker, pastor, and radio host, Charlana Kelly as she shares wisdom you need for the coming days. We live in perilous times, but we need not fear. The good news is, the Holy Spirit will help us and empower us to overcome every obstacle. The times call for a hearing heart and reverential obedience. God wants to speak directly to us, but we have to have an ear to hear and a heart to follow.
Connect with Charlana on Facebook and Twitter at either @charlanakelly or @avoice4ourtime, also on the web at avoiceforoutime.net. A Voice for Our Time is the flagship program on Voices of Truth Radio Network, a SpeakTruth Media production © 2015.
Forget the old dating advice of no sex on the first
date, how about no sex on any date? 36-year old Kim
Brooks is a virgin who dates regularly. She’ll share
the true meaning of intimacy less sex, how to chase a
man without chasing him and get him to ask you out, and
how sexless relationships can make you irresistible to
any man and get him to open up like never before. Kim
will empower your audience with tools to take them from
feelings of pain and disappointment to completeness,
expectation and joy. They’ll gain control of their
love lives and get what they want out of a relationship
– all without any promise of sex until after marriage.
Kim Brooks is the author of “She That Findeth.” Contact
This week we are joined by Jon Pressick: Editor of Best Sex Writing of The Year, host of Sex City and blogger of Sex in Words!
Best Sex Writing of the year is a collection of sex related internet pieces by an eclectic mix or authors. From gender fuild adult film star Jizz Lee to notorious college girl / star Belle Knox
On this Wednesday May 27th, 2015 Negdog @negdog is celebrating 3 years on the air! Special guest the 813 Legendary Coach Kerry Bender and now the Tampa Bay Buccaneers #1 Super Fan. He helped launch the show on Episode 1! I'll have Another was going for the Triple Crown and now American Pharoah is trying to break the 37 year drought. We will talk about the beginnings of BlueChipperUniversity.com and the scholar athletes helped over the seasons! EDM rave @ RayJay. Our Fugazi of the day and our Platinum selection of the day from The Underground Sports Network. Call in to the Studio live! www.negdog.com www.bluechipperuniversity.com
My daughter is graduating from high school and going off to college in the Fall and this month I finish up a nine month yoga teacher training, and I am having a significant birthday ushering in a new decade- these events and several others got me thinking about the true and possible meanings with beginnings and endings.
Beginnings and endings- they are constantly occurring in our lives, but how often do we stop to recognize, celebrate and make the most of them? Everything that is beginning is ending something else, and everything that is ending provides a new beginning. Join in the conversation about ways to make the most of what is happening in life and using these times to enhance and expand what you want to create in your life. Events, education, relationships, work and career, travel, even new weeks months and years- we will talk about all of it. Leave the show feeling fueled to make these life milestones more meaningful and purposeful!
Join us Tuesday 7 April 2015 @ 9:30pm for MHHS-Eyes Wide Open presents:
Principals of Nationality in Action where we will discuss:
What happened Astrologically on the day identified as “Easter” ?
Once we get to spring, the time of year when the Sun, in astrological terms, is considered exalted, the Sun will be resurrected in the sign of Aries. However, despite what’s happened in modern culture, the story of the Sun’s resurrection is incomplete without the feminine symbol of the Moon.
Easter Sunday can only happen after the first full moon in spring. Spring, of course, means that the Sun rises at the equator, creating more equal days and night. And there is Moor …
This is the Uniting of Asia - Family
We must activate our voice with law and speak with our Writs!!!
Listen via the internet at www.blogtalkradio.com/mhhs-eyeswideopen, or call 347-945-5899, Press '1' to speak to the Host and for those listening via the Internet, the Chat Room will be open immediately.
Remember to check us out on Facebook: https://www.facebook.com/MHHSEyesWideOpen, and please select like. Also we are also on Twitter: http://www.twitter.com/MHHSEyesWideOpn
Please also send us an email @ firstname.lastname@example.org so we can compile an email list for blitzing and also send us emails with the appellation, Corporate State and/or county along with ransom amount for any Moor who has been kidnapped and is currently being held hostage.
Thank you, this is greatly appreciated. We here at Moor Heritage and History School Eyes Wide Open thank you for coming together so that we may together be uplifted.
Moors Heritage & History School in association with RVBey Publications, Moorish Nation Public Records, Moorish News
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