Parkinson’s disease (PD) is a systemic disease with motor and non-motor deficits. In July 2011, we treated a 47-year-old man affected by spinocerebellar ataxia type 2 (SCA2). In this patient, fatigue as well as motor symptoms improved after parenteral high doses of thiamine (also this was our proprietary research). Therefore, we formulated the hypothesis that in some inherited and degenerative diseases of the nervous system, the pathogenesis of the symptoms could be linked to a focal thiamine deficiency due to a dysfunction of the circulation of thiamine in the intracellular space or to structural enzymatic abnormalities. We thought that this dysfunction could be responsive to high-dose thiamine. Furthermore, PD has also been related to mutations associated with SCA2. Applying the same approach to the PD the observed results were nothing short of startling and never previously described in literature.
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