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The measles virus used successfully for a patient with relapsed myeloma is now a well known and exciting story shared on maintstream media. Dr. Frits van Rhee MD PhD MRCP, FRCPath and Dr. Stephen Russell, MD PhD FRCP, FRCPath take the success one step further with a Phase II trial of the measles virus with further engineering in patients with relapsed/refractory, high-risk multiple myeloma. Their work will help determine which patients will respond to the treatment and which ones will not and will also determine how to make the therapy more effective.